INDIVIDUAL PEPTIDES
Acetyl Tetrapeptide-2 is a cosmetic ingredient candidate for firmness and age-care formulas. Review its identity and cell-study evidence, then share your target area, material form and evaluation stage to request relevant documents, samples or pricing.
On this page Overview Identity Review Questions Enquire →
- Catalogue reference
- KI-035
- Product family
- Individual peptides
- CAS reference
- 757942-88-4
- Public INCI identity reference
- Acetyl Tetrapeptide-2
The public overview identifies the catalogue material. Confirm the supplied grade, full composition and current batch specifications in the supplier documents.
Development directions
Firmness and age-care concepts: specify the facial or neck area and a finished-product appearance or biomechanical endpoint. A published study measured cultured HaCaT cell stiffness after 48 hours. That cell endpoint does not establish human skin lifting, a visible contour change or a cosmetic use level.
Possible formulation formats
- Facial firmness serum
- Neck-care cosmetic cream
- Age-care emulsion ingredient evaluation
Formulation concepts for evaluation. Review the actual supplied material and finished formula for the intended cosmetic use.
Identity and supplied form
The public CAS 757942-88-4 record describes Ac-Lys-Asp-Val-Tyr-OH, with an N-acetyl group and free-acid C-terminus. Confirm sequence, terminal form, counterions and peptide-content basis when comparing offers. A reference solution and the individual peptide are different supplied forms even when their ingredient names match.
Cell stiffness is not a clinical lifting result
The 2018 paper in International Journal of Peptide Research and Therapeutics studied Acetyl Tetrapeptide-2 and Acetyl Hexapeptide-50 in immortalized HaCaT keratinocytes. Atomic force microscopy measured cell stiffness after 48-hour exposure. The tested peptides came as prepared solutions. These are in vitro observations, rather than a human comparison of finished creams, and they do not quantify a visible lifting effect.
Compare the material for your brief
If your reference is an Uplevity formulation, the 2015 Lubrizol brochure declares water, Acetyl Tetrapeptide-2 and caprylyl glycol. Keep that preparation separate from a neat-peptide request. Compare full composition, peptide content and the endpoint behind each claim before transferring formulation conditions or comparing cost on a percentage basis.
Formulation review priorities
| Review point | What to establish |
|---|---|
| Material basis | Match the required Ac-KDVY-OH identity, counterions and peptide content before comparing individual peptides and preparations. |
| Study relevance | Keep 48-hour cell-stiffness observations separate from human appearance, elasticity and contour endpoints. |
| Evaluation design | State the intended area, formula, matched comparison and observation period for your cosmetic assessment. |
Public reference sources
PubChem: Acetyl Tetrapeptide-2 identity →
2018 HaCaT study: full paper →
Lubrizol 2015 Uplevity brochure →
Reference review: 27 October 2026. These public sources describe identity, research or third-party preparations. Confirm the exact offered material and its current documents for your project.
Questions for your brief
- Which cosmetic area and endpoint will you evaluate?
- What material form and peptide content are required?
- What sample quantity, destination and documents do you need?
Does the HaCaT study demonstrate a lifting cream?
No. It measured mechanical properties in cultured keratinocytes. A visible lifting or firmness claim for a cream requires relevant finished-product evidence and an appropriate comparison, rather than direct transfer from cell stiffness.
Can an Uplevity preparation specification define this offered material?
No. It describes that reference preparation. Confirm the exact offered composition and current documents, including peptide content and handling guidance, before interpreting its formulation percentages or substituting a different supplied form.
Related catalogue directions
Compare Palmitoyl Tripeptide-5 →